Espero que disfrutes del juego. (2nd person singular, informal)
Espero que disfrute del juego. (2nd person singular, formal)
Espero que disfruten del juego. (2nd person plural, formal)
Espero que disfrutéis del juego. (2nd person plural, informal)
Both 1 and 2 are correct. Formal versions are the "usted" forms and they also depend on country or region within country, but everyone understands both.